The main riff is primarily a bass line, but the guitar fills are huge and distorted. Mesa Dual Rectifier gives the right heaviness.
Signal Chain
Mesa Boogie Dual Rectifier→Mesa 4x12 V30→Output
AmpMesa Boogie Dual Rectifier
bass
6
gain
8
mids
5
treble
7
channelModern
presence
6
Cab / IRMesa 4x12 V30
micSM57
mic positioncenter cap
Notes
Heavy, saturated distortion. The guitar locks with the bass on the main riff.