Clapton used a Les Paul through a Fender Champ (clean) and a Marshall for crunch. The interplay between the two guitars is legendary.
Signal Chain
Vox Wah→Marshall JTM45→4x12 Greenback→Output
PedalVox Wah
mix
5
AmpMarshall JTM45
bass
6
gain
7
mids
7
treble
6
presence
5
Cab / IR4x12 Greenback
micSM57
mic positionoff-axis
Notes
The famous lick alternates between guitar 1 (Clapton) and guitar 2 (Duane Allman). Learn both parts!