Appetite Lead Voice — Intro & Wah Climax
Slash’s core Appetite for Destruction chain was the Kris Derrig 1959 Les Paul replica with Seymour Duncan Alnico II Pro pickups into SIR Stock #36, a modified 100-watt Marshall. A Roland SRV-2000 supplied the spacious digital reverb, while the final solo section switches from the warm neck-pickup voice to bridge pickup and stock Cry Baby wah. Exact amplifier controls and mic placement were not published, so those values are representative. Source: Guitar.com, Seymour Duncan, Vintage Digital, and Guitar World.
Signal Chain
Notes
Use less preamp gain and more output volume than a modern lead preset. Strong upper mids, controlled bass, wide vibrato, and precise bends matter more than extra saturation.
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See the same signal chain mapped to another platform. Knob values carry over as starting points — gain ranges differ between platforms.